Hydrochloric Acid → HCID 86707571, compound

Participants

Reaction Conditions

Reaction Steps

2.20 g (4.15 mmol) 3-{3″-fluoro-5′-(2-methoxy-ethoxymethoxy)-4-[2-(2-methoxy-ethoxymethoxy)-ethoxy]-[1,1′;3′,1″]terphenyl-4″-yloxy}-propane-1-ol are dissolved in 25 ml methanol and after addition of 3 ml conc. hydrochloric acid heated overnight at 50° C. The solvent is removed in vacuo, the crude product is dissolved in MTB ether, washed with water and sat. aq. sodium chloride solution, and dried over sodium sulfate. The solvent is removed in vacuo and the crude product is crystallized from dichloromethane. 3″-Fluoro-4-(2-hydroxy-ethoxy)-4″-(3-hydroxy-propoxy)-[1,1′;3′,1″]terphenyl-5′-ol is obtained as colourless crystals.

Provenance & Evidence