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HRID227997

反应详情

EQUATION

反应方程式

HRID 227997 的结构方程式

REACTANTS

反应物

2
结构：Nc1nc(C2CC2)cs1
HCID674456

4-Cyclopropylthiazol-2-amine

C6H8N2S

结构：N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)O)(CC1)CC2
HCID57634365

未命名化合物

PRODUCTS

生成物

1
结构：N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)Nc3nc(C4CC4)cs3)(CC1)CC2
HCID57756758

未命名化合物

收率 62.6%

PROCEDURE

实验过程

In a similar manner to Example 87, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 2-amino-4-cyclopropylthiazole (47.7 mg) were used to obtain (2S,4S)-1-[[N-[4-[N-(4-cyclopropylthiazol-2-yl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (43.1 mg).