HCID 86707584, compound → HCID 86707583, compound

Participants

Reaction Steps

2.50 g (3.55 mmol) 4,4″-bis-[3-(2-methoxy-ethoxymethoxy)-propyl]-5′-(4-benzyloxyphenyl)-[1,1′;3′,1″]terphenyl are hydrogenated in 70 ml THF on Pd/activated charcoal until the reaction is completed. The catalyst is filtered off, the solvent is removed in vacuo, the residue is dissolved in 20 ml THF, 5 ml 25% hydrochloric acid are added dropwise under cooling and the mixture is stirred overnight at RT. After addition of 100 ml MTB ether the solution is washed with water and sat. aq. sodium chloride solution and dried over sodium sulfate. The solvent is removed in vacuo and the residue is filtered through silica gel with dichloromethane/MTB ether (9:1), to give 3-[4″-(3-hydroxy-propyl)-5′-(4-hydroxyphenyl)-[1,1′;3′,1″]terphenyl-4-yl]-propane-1-ol as colourless oil.

Provenance & Evidence