Tetrahydrofuran → HCID 86707588, compound

Participants

Reaction Conditions

Reaction Steps

5.40 g (7.82 mmol) 3-benzyloxy-propionic acid-4″-(3-benzyloxy-propionyloxy)-5′-(2-methoxy-ethoxymethoxy)-[1,1′;3′,1″]terphenyl-4-yl ester are dissolved in 40 ml isopropanol and 10 ml THF and after addition of 1.97 g (7.82 mmol) pyridiniumtosylate are stirred for 60 h at 70° C. After cooling to RT the mixture is diluted with MTB ether, washed with sat. aq. sodium chloride solution and dried over sodium sulfate. The solvent is removed in vacuo and the residue is hydrogenated in 40 ml THF on Pd/activated charcoal until the reaction is completed. The solvent is removed in vacuo and the crude product is recrystallized from dichloromethane, to give 3-hydroxy-propionic acid-5′-hydroxy-4″-(3-hydroxy-propionyloxy)-[1,1′;3′,1″]terphenyl-4-yl ester as colourless crystals.

Provenance & Evidence