p-Toluenesulfonic acid → HCID 118199438, compound

Participants

Reaction Steps

1,3-Dioxane, 2-boc amino (10C) (18 mg, 0.05 mmol) and 10 mol % TsOH (1.0 mg, 0.005 mmol) were combined in 5.0 mL 80% EtOH (in H2O) and stirred at reflux for 1 h, until the starting material was consumed as indicated by TLC (5:3/CH2Cl2:EtOAc). The reaction mixture was quenched with 5% NaHCO3, and removed in vacuo. Purification by flash column chromatography on silica gel afforded the desired product as a white solid (92%).

Provenance & Evidence