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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2280004Generated: October 30, 2026

Methyl iodide → 2-Chloro-9-cyclopentyl-5,7,7-trimethyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one

https://huagongshe.com/reaction/2280004

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl iodideHCID 6328—
ReactantSodium hydrideHCID 24758—
Reactant2-Chloro-9-cyclopentyl-7,7-dimethyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-oneHCID 58154012—
SolventDimethylformamideHCID 6228—
Product2-Chloro-9-cyclopentyl-5,7,7-trimethyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-oneHCID 59295116—

Reaction Steps

Reaction of 2-chloro-9-cyclopentyl-7,7-dimethyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one with MeI and NaH in DMF gave 2-chloro-9-cyclopentyl-5,7,7-trimethyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09133199B2
Source datasetuspto-grants-2015_09
ORD IDord-62ef088c28be44f8a433eeb4f7edb33c
Source noteuspto-grants-2015_09