p-Aminophenylacetic acid ethyl ester → HCID 57756772, compound

Participants

Role	Name	HCID	Charge
Reactant	p-Aminophenylacetic acid ethyl ester	HCID 225219	—
Reactant	(2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile	HCID 57634365	—
Product	HCID 57756772	HCID 57756772	44.8%

Reaction Steps

In a similar manner to Example 63, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and ethyl 4-aminophenylacetate (61.0 mg) were used to obtain (2S,4S)-1-[[N-[4-[N-(4-ethoxycarbonylmethylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (33.6 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07560569B2
Source dataset	uspto-grants-2009_07
ORD ID	ord-f6863798ef2d4f388c65cbfc79f9d74a
Source note	uspto-grants-2009_07