Dimethylamine → HCID 72547091, compound

Participants

Reaction Conditions

Reaction Steps

Follows general procedure E: Ruphos palladacycle (1.5 mg, 0.0020 mmol), LHMDS (0.14 mL, 0.14 mmol), naphthalene (0.016 g, 0.072 mmol), THF (0.20 mL), and dimethylamine (54 μL, 0.11 mmol). The reaction mixture was heated at 85° C. for 1.5 h, turning the reaction mixture dark brown over time. The crude product was purified by silica gel flash column chromatography (1.5 cm, 5% ethyl acetate/hexanes) to yield the title compound as a yellow solid (8 mg, 50%).

Provenance & Evidence