N-methyl-2-pyrrolidone → HCID 71225831, compound

Participants

Reaction Conditions

Reaction Steps

2-[2-chloro-4-(2,4-difluorophenoxy)phenyl]-2-methyl-oxirane (5.0 g), triazole (5.24 g) and NaOH (1.52 g) were dissolved in NMP (50 mL) and the reaction mixture heated to 120° C. and stirred for 15 h. The reaction mixture was diluted with MTBE (200 mL) and extracted three times with 100 mL H2O. The organic phase was washed with sat. aq. NaCl-sol and dried over Na2SO4. After evaporation and column chromatography (CH2Cl2/MeOH, O-20% MeOH), 2-[2-chloro-4-(2,4-difluorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol (2.7 g) was obtained as an orange oil.

Provenance & Evidence