Sodium Hydroxide → 2-Pyrimidineacetic Acid

Participants

Reaction Steps

To a solution of ethyl 2-(pyrimidin-2-yl)acetate (Example 31b, 410 mg. 2.47 mmol) in ethanol (5 mL) was added 2N NaOH (2 mL) at room temperature under nitrogen. The reaction mixture was stirred at room temperature under nitrogen for 72 hours, then concentrated under reduced pressure. The residue was triturated with ethanol and concentrated under reduced pressure to give the title compound, which was carried onto the next step without further purification. MS139 (MH+).

Provenance & Evidence