HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2280185Generated: October 30, 2026
Imidazole → 2-(1H-Imidazol-1-yl)pyridine-4-carboxylic acid
https://huagongshe.com/reaction/2280185
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Bromoisonicotinic acid | HCID 222701 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-(1H-Imidazol-1-yl)pyridine-4-carboxylic acid | HCID 26967253 | 108% |
Reaction Steps
To a solution of 2-bromoisonicotinic acid (1.87 g. 9.26 mmol), 1H-imidazole (573 mg, 8.42 mmol) and Cs2CO3 (6.03 g, 18.5 mmol) in DMSO (18.6 mL), was added CuI (176 mg, 0.926 mmol). The mixture was heated to 125° C., stirred for 18 hours, cooled to room temperature, filtered and purified by preparative HPLC (10-90% acetonitrile in water) to give the title compound as a light pink solid (1.72 g, 98%). MS 190 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09138013B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-1c35194b1e7249c0b189a2c72bce88d7 |
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| Source note | uspto-grants-2015_09 |
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