Hydrochloric Acid → HCID 86731035, compound

Participants

Reaction Steps

To a mixture of 1-{[(4aR,6R,8aR)-2-amino-3-cyano-8-methyl-4H,4aH,5H, 6H,7H,8H,8aH,9H-thieno[3,2-g]quinolin-6-yl]carbonyl}-3-[2-(dimethylamino)ethyl]-1-propylurea (compound 1-1) (10.0 g) and ethanol (200 mL) was added dropwise a mixture of 12 mol/L hydrochloric acid (3.91 mL) and ethanol (30 mL) while stirring under ice bath cooling, and the mixture was stirred at the same temperature for 3 hours. The resulting solid was collected by filtration, and washed twice with ethanol (20 mL) to give 1-{[(4aR,6R,8aR)-2-amino-3-cyano-8-methyl-4H,4aH,5H,6H,7H,8H,8aH,9H-thieno[3,2-g]quinolin-6-yl]carbonyl}-3-[2-(dimethylamino)ethyl]-1-propylurea di hydrochloride salt (11.5 g).

Provenance & Evidence