4-Acetylamino-4-(2-tert-butoxycarbonyl-ethyl)-heptanedioic acid di-tert-butyl ester → 4-Acetylamino-4-(2-carboxy-ethyl)-heptanedioic acid

Participants

Reaction Steps

1.5 g of triester 63 (3.28 mmol) was added to 20 ml formic acid (96%) and stirred for 4 hours. After this time the formic acid was removed by azeotropic distillation with 5×20 ml portions of toluene. The crude residue was recrystallised from EtOH and petroleum spirit to give 0.9 g of off white crystals in 93% yield.

Provenance & Evidence