Butyric Acid → HCID 71208937, compound

HRID 2280250Notes

Reaction equation

HRID 2280250 reaction equation
[O:1]1[CH2:7][CH:6]([N:8]2[C:12]3=[N:13][CH:14]=[N:15][C:16]([NH2:17])=[C:11]3[C:10]([C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)=[CH:20][CH:19]=3)=[N:9]2)[CH2:5][NH:4][CH2:3][CH2:2]1.[C:31](O)(=[O:35])[CH2:32][CH2:33][CH3:34]>>[NH2:17][C:16]1[N:15]=[CH:14][N:13]=[C:12]2[N:8]([CH:6]3[CH2:7][O:1][CH2:2][CH2:3][N:4]([C:31](=[O:35])[CH2:32][CH2:33][CH3:34])[CH2:5]3)[N:9]=[C:10]([C:18]3[CH:19]=[CH:20][C:21]([O:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)=[CH:22][CH:23]=3)[C:11]=12

Participants

3

Reactant 2

HCID 264Butyric AcidHCID 71208634HCID 71208634, compound

Product 1

HCID 71208937HCID 71208937, compound

Procedure

1-(1,4-oxazepan-6-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is coupled with butyric acid under basic condition to afford title compound in good yield.

Sources & evidence

ORD record
ord-74cff50de1244d8093e947fc95f95746
Source dataset
uspto-grants-2015_09
Patent number
US09138436B2

Reaction notes

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