Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 71208757 | HCID 71208757 | — |
| Product | HCID 71208810 | HCID 71208810 | — |
Reaction Steps
The solution of compound 10 (200 mg, 1.1 mmol) and HATU (439 mg, 1.1 mmol) in 10 mL of DMA was stirred at 25° C. for 10 mins. Then it was added to the solution of compound A (400 mg, 1.1 mmol) and DIPEA (298 mg, 2.3 mmol) in 10 mL of DMA, and the mixture was stirred at 25° C. for 3 h. The reaction was monitored by LC-MS, and purified by prep-HPLC to give 76 mg of the title compound (1g). MS (ESI) m/e (M+1H)+: 528.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09138436B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-af1c2e368ed54636810a12e49c31e2a1 |
|---|
| Source note | uspto-grants-2015_09 |
|---|
