HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Thienylmethyl)amine → HCID 57756767, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Thienylmethyl)amine | HCID 34005 | — |
| Reactant | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| Product | HCID 57756767 | HCID 57756767 | 75.4% |
Reaction Steps
In a similar manner to Example 92, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 2-thienylmethylamine (38.5 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-[N-(2-thienylmethyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (48.8 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560569B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-1aa2a744abb244af8eb34cf2997ff9fd |
| Source note | uspto-grants-2009_07 |