Potassium Acetate → HCID 67179790, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-[1-(4-Carbamoyl-2-methyl-phenyl)-5-(4-iodo-phenyl)-1H-pyrrol-2-yl]-propanoic acid ethyl ester (127 mg, 0.252 mmol), 1H-pyrazole boronic acid pinacol ester (147 mg, 0.75 mmol), potassium acetate (222 mg, 2.3 mmol), and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (60.0 mg, 0.074 mmol) in anhydrous DMF (4 mL) was degassed with nitrogen and then heated at 100° C. for 16 h. The mixture was then diluted with ethyl acetate (50 mL) and washed with water (30 mL). After drying the organic layer over anhydrous Na2SO4, the solvent was removed to obtain a crude product which is purified by silica gel flash chromatography (33 mg, 28%).

Provenance & Evidence