HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2280294Generated: October 30, 2026
Oxalyl chloride → 1,3-BENZOTHIAZOLE-6-CARBONYL CHLORIDE
https://huagongshe.com/reaction/2280294
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Benzothiazole-6-carboxylic acid | HCID 601670 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1,3-BENZOTHIAZOLE-6-CARBONYL CHLORIDE | HCID 12208022 | 150.4% |
Reaction Steps
Under a nitrogen atmosphere, benzothiazole-6-carboxylic acid (1.014 g, 5.6 mmol) was dissolved in methylene chloride (25 mL). Five drops of N,N-dimethylforamide was added. Oxalyl chloride (0.5 mL, 5.6 mmol) was slowly added. After 2 hrs, the reaction was heated to 30° C. for 16 hrs. The reaction was concentrated in vacuo to yield benzothiazole-6-carbonyl chloride (19A) (1.665 g, quant., light yellow powder).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09138427B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-aa27aa48828f41f398d914f3d798210f |
|---|
| Source note | uspto-grants-2015_09 |
|---|
