4-amino-3-methylbenzamide → HCID 67179471, compound

HRID 2280321Notes

Reaction equation

HRID 2280321 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][CH2:10][C:11](=O)[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:4][CH:3]=1.[NH2:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([NH2:27])=[O:26])=[CH:23][C:22]=1[CH3:30]>O1CCOCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:20]([C:21]3[CH:29]=[CH:28][C:24]([C:25](=[O:26])[NH2:27])=[CH:23][C:22]=3[CH3:30])[C:11]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 121180574-amino-3-methylbenzamideHCID 58297651HCID 58297651, compound

Product 1

HCID 67179471HCID 67179471, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

37C, R═Br was cyclized following step 3 of Scheme 1 with 4-amino-3-methylbenzamide with a different solvent, dioxane.

Sources & evidence

ORD record
ord-816c2c81f92640baa8a0735899f95732
Source dataset
uspto-grants-2015_09
Patent number
US09138427B2

Reaction notes

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