Acetohydroxamic Acid → HCID 67180081, compound

Participants

Reaction Steps

In 4 mL of dry DMF was dissolved acetohydroxamic acid (57 mg, 0.765 mmol), followed by potassium t-butoxide (86 mg, 0.765 mmol) at ambient temperature. After this mixture had been stirred for 30 min, compound 47-1 (200 mg, 0.510 mmol) was added and stirred overnight. The reaction mixture was poured into a mixture of brine (30 mL) and ethyl acetate (30 mL). The organic phase was separated, the aqueous layer was extracted EA (20 mL×3). The combined organic phase was washed with brine (30 mL), dried over anhydrous Na2SO4, filtered, concentrated and purified by silica gel column chromatography (PE:EA=1:1) to afford 47-2 as a yellow oil (80 mg, 39%).

Provenance & Evidence