HRID228034

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID26444

1,3,4-Thiadiazol-2-amine, 5-ethyl-

C4H7N3S

结构：N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)O)(CC1)CC2

HCID57634365

未命名化合物

PRODUCTS

生成物

结构：CCc1nnc(NC(=O)C23CCC(NCC(=O)N4C[C@@H](F)C[C@H]4C#N)(CC2)CC3)s1

HCID57756789

未命名化合物

收率 51.8%

PROCEDURE

实验过程

In a similar manner to Example 87, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 2-amino-5-ethyl-1,3,4-thiadiazole (43.9 mg) were used to obtain (2S,4S)-1-[[N-[4-[N-(5-ethyl-1,3,4-thiadiazol-2-yl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (34.8 mg).