5-Nitro-2,3-dihydro-1,3-benzoxazol-2-one → 5-Amino-2,3-dihydro-1,3-benzoxazol-2-one

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Reaction Steps

The mixture of 39-1 (5.1 g, 28.31 mmol), Pd/C (0.5 g) and HCO2NH4 (8.9 g, 141.57 mmol) in MeOH (200 mL) was stirred at room temperature overnight. Filtered with kiselguhr, concentrated in vacuo, the residue was added 5% NaHCO3 solution, collected the solid and washed with water (50 mL), dried in vacuo to get compound 39-2 as a brown solid (4 g, yield 94%).

Provenance & Evidence