HCID 66611341, compound → HCID 66611481, compound

Participants

Reaction Steps

In a dry pressure vessel, 0.83 g (2.2 mmol) of benzyl-{3,3-difluoro-1-[3-(4-fluoro-phenoxy)propyl]piperidin-4-yl}amine 15 was dissolved in 10 mL of methanol. After adding 0.33 g (40 wt %) of Pd/C (10%) at 0° C., the mixture was stirred during 15 hours at room temperature under hydrogen pressure of 480 kPa. The mixture was filtered over diatomaceous earth. The solvent was evaporated in vacuo to yield 0.57 g (2.0 mmol; 90% yield) of 3,3-difluoro-1-[3-(4-fluorophenoxy)propyl]piperidin-4-amine 16 as a yellow oil.

Provenance & Evidence