反应详情

4-Benzyloxy-2-fluoro-benzoic acid (2 g, 8.12 mmol) was suspended in thionyl chloride (5.9 mL) and heated to reflux for 30 minutes. The reaction mixture was then concentrated under reduced pressure, and the resulting residue was dissolved in toluene and re-concentrated twice to remove residual thionyl chloride. This procedure provided the title compound in crude form, which was used in the next reaction without further purification.

1. temperatureheated
2. temperatureto reflux for 30 minutes
3. concentrationThe reaction mixture was then concentrated under reduced pressure
4. dissolutionthe resulting residue was dissolved in toluene
5. concentrationre-concentrated twice
6. customto remove residual thionyl chloride