HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-fluorophenyl)-1,3-thiazol-2-amine → HCID 57756860, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-fluorophenyl)-1,3-thiazol-2-amine | HCID 722371 | — |
| Reactant | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| Product | HCID 57756860 | HCID 57756860 | 65.5% |
Reaction Steps
In a similar manner to Example 87, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 2-amino-4-(4-fluorophenyl)thiazole (66.1 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-[N-[4-(4-fluorophenyl)thiazol-2-yl]amino)carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (50.6 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560569B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-f4e4424020f7442da606636bfe6e6ee2 |
| Source note | uspto-grants-2009_07 |