HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Chloroquinolin-6-ol → 3-(3-fluoro-4-(6-hydroxyquinolin-2-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Chloroquinolin-6-ol | HCID 22132577 | — |
| Edukt | 4-Cyano-2-Fluorophenylboronic Acid | HCID 44755209 | — |
| Edukt | HCID 136078979 | HCID 136078979 | — |
| Produkt | 3-(3-fluoro-4-(6-hydroxyquinolin-2-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one | HCID 136078983 | — |
Reaktionsschritte
Followed procedure described for Compound 20 in Example 20 starting from 2-chloroquinolin-6-ol (Intermediate 2) and 4-cyano-2-fluorophenylboronic acid. 1H NMR (DMSO-d6, 300 MHz): δ 10.22 (1H, s), 8.27-8.33 (2H, m), 7.97 (1H, d, J=9 Hz), 7.77-7.82 (2H, m), 7.39 (1H, dd, J=3, 9 Hz), 7.21 (1H, d, J=3 Hz) ppm. MS (ESI): m/z 324.0 [M+1]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09139528B2 |
| Quelldatensatz | uspto-grants-2015_09 |
| ORD ID | ord-c262253930e646b2b01440ac07cce221 |
| Quellennotiz | uspto-grants-2015_09 |