HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2280456Generated: October 31, 2026
Ethyl Acetate → Tert-butyl 2-(4-(6-hydroxyquinolin-2-yl)benzoyl)hydrazinecarboxylate
https://huagongshe.com/reaction/2280456
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | tert-Butyl carbazate | HCID 70091 | — |
| Reactant | 4-(6-Hydroxyquinolin-2-yl)benzoic acid | HCID 56960775 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Tert-butyl 2-(4-(6-hydroxyquinolin-2-yl)benzoyl)hydrazinecarboxylate | HCID 66980037 | 70% |
Reaction Steps
A mixture of 4-(6-hydroxyquinolin-2-yl)benzoic acid (Compound 3, Example 3) (200 mg, 0.754 mmol), EDCI (145 mg, 0.754 mmol) and BocNHNH2 (100 mg, 0.754 mmol) in DCM (10 mL) and DMF (10 mL) was stirred at 25° C. overnight, followed by an aqueous/EtOAc workup. The crude was purified by column chromatography on silica gel (PE/EtOAc=1/1) to give the product (200 mg, yield 70%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09139528B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-c22f7af5d1b24560b9df2d5c8a7f89e9 |
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| Source note | uspto-grants-2015_09 |
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