HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3,3-trifluoro-N-(2-(hydroxymethyl)-4-methoxyphenyl)propanamide → 3,3,3-trifluoro-N-(2-formyl-4-methoxyphenyl)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3,3-trifluoro-N-(2-(hydroxymethyl)-4-methoxyphenyl)propanamide | HCID 66980052 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3,3,3-trifluoro-N-(2-formyl-4-methoxyphenyl)propanamide | HCID 86689938 | 84.9% |
Reaction Steps
To a solution of 3,3,3-trifluoro-N-(2-(hydroxymethyl)-4-methoxyphenyl)propanamide (6.30 g, 23.9 mmol) in anhydrous CH2Cl2 (200 mL) was added MnO2 (20.0 g, 229 mmol). The mixture was refluxed for 16 hours. The mixture was filtered off and the filtrate was concentrated to give the desired product (5.30 g, yield 84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139528B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-ab02955133144ef484e3df3513f1843f |
| Source note | uspto-grants-2015_09 |