HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Adamantan-1-yl-[1,3,4]thiadiazol-2-ylamine → HCID 57756844, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Adamantan-1-yl-[1,3,4]thiadiazol-2-ylamine | HCID 704888 | — |
| Reactant | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| Product | HCID 57756844 | HCID 57756844 | 67.8% |
Reaction Steps
In a similar manner to Example 87, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 5-adamantyl-2-amino-1,3,4-thiadiazole (80.0 mg) were used to obtain (2S,4S)-1-[[N-[4-[N-(5-adamantyl-1,3,4-thiadiazol-2-yl)amino]carbonylbicyclo[2.2.2)oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (56.7 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560569B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-844e6b0d9fbe46de8db5e13686419e82 |
| Source note | uspto-grants-2009_07 |