HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 8-Fluoro-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 8-Fluoro-6-hydroxy-3,4-dihydroquinolin-2(1H)-one | HCID 10375048 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Fluoro-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl acetate | HCID 9991144 | 54% |
Reaction Steps
Crude 8-fluoro-6-hydroxy-3,4-dihydroquinolin-2(1H)-one (0.574 g) was treated with acetyl chloride (330 mg) and TEA (0.68 mL) in DCM (8 mL) over 3 h. After aqueous work-up with EtOAc/water, the crude product was purified with a flash column chromatography to afford the desired product (382 mg) as colorless solids.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139528B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-7d81a2f518864acbadeed7e0b8f7728b |
| Source note | uspto-grants-2015_09 |