HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2280506Generated: October 31, 2026
Phosphorus oxychloride → HCID 86689940, compound
https://huagongshe.com/reaction/2280506
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178475467 | HCID 178475467 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86689940 | HCID 86689940 | — |
Reaction Steps
To a solution of 8-fluoro-2-hydroxyquinolin-6-yl acetate (550 mg) in DMF (6 mL) was added POCl3 (0.6 mL). Then, the mixture was heated at 80° C. over a couple of hours. After aqueous work-up, the desired product, 2-chloro-8-fluoroquinolin-6-yl acetate (380 mg) was obtained by flash silica column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09139528B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-bb5f82fbe5e74e9d915b63bd2e2d1f62 |
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| Source note | uspto-grants-2015_09 |
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