Trifluoroacetic acid → HCID 68846629, compound

Participants

Reaction Steps

(2S,4S)-4-Fluoro-1-[[N-[4-[N-[4-(1,1-dimethylethyloxycarbonyl)phenyl]amino]carbonylbicyclo[2.2.2]oc t-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (23.0 mg) was dissolved in dichloromethane (0.2 mL). To this solution, trifluoroacetic acid (0.2 mL) was added and the mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was concentrated under reduced pressure to give (2S,4S)-4-fluoro-1-[[N-[4-[N-(4-carboxyphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile trifluoroacetate (24.5 mg).

Provenance & Evidence