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HRID228055

反应详情

EQUATION

反应方程式

HRID 228055 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)c1nnc(N)s1
HCID2756556

ethyl 5-amino-1,3,4-thiadiazole-2-carboxylate

C5H7N3O2S

结构：N#C[C@@H]1C[C@H](F)CN1C(=O)CNC12CCC(C(=O)O)(CC1)CC2
HCID57634365

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)c1nnc(NC(=O)C23CCC(NCC(=O)N4C[C@@H](F)C[C@H]4C#N)(CC2)CC3)s1
HCID57756799

未命名化合物

收率 43.1%

PROCEDURE

实验过程

In a similar manner to Example 87, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and ethyl (5-amino-1,3,4-thiadiazole-2-carboxylate) (58.9 mg) were used to obtain (2S,4S)-1-[[N-[4-[N-(5-ethoxycarbonyl-1,3,4-thiadiazol-2-yl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (31.9 mg).