HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1-adamantyl)-1,3-thiazol-2-amine → HCID 57756837, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1-adamantyl)-1,3-thiazol-2-amine | HCID 616434 | — |
| Reactant | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| Product | HCID 57756837 | HCID 57756837 | 35.3% |
Reaction Steps
In a similar manner to Example 87, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 4-adamantyl-2-aminothiazole (79.7 mg) were used to obtain (2S,4S)-1-[[N-[4-[N-(4-adamantylthiazol-2-yl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (29.5 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560569B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-de6230d21b5d4bcd9b858d7e05f808b5 |
| Source note | uspto-grants-2009_07 |