HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2280569Generated: November 1, 2026
Thionyl Chloride → 2-chloroquinoline-3-carbonyl chloride
https://huagongshe.com/reaction/2280569
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Chloroquinoline-3-carboxylic acid | HCID 847163 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 2-chloroquinoline-3-carbonyl chloride | HCID 2794665 | — |
Reaction Steps
To 2-chloroquinoline-3-carboxylic acid (5 g, 24.08 mmol) was added thionyl chloride (22.83 mL, 313.0 mmol) and DMF (12 drops) and the reaction was heated at 60° C. for 16 hours. The excess thionyl chloride and N,N-dimethyl formamide were removed in vacuo to yield 2-chloroquinoline-3-carbonyl chloride as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09139529B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-5684e9e70ab741be8e55b5900f7fff4b |
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| Source note | uspto-grants-2015_09 |
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