HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2280576Generated: October 31, 2026
Benzenesulfonamide, 3-amino- → HCID 86729562, compound
https://huagongshe.com/reaction/2280576
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzenesulfonamide, 3-amino- | HCID 7377 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 2-Chloroquinoline-3-carboxylic acid | HCID 847163 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86729562 | HCID 86729562 | — |
Reaction Steps
2-Chloroquinoline-3-carboxylic acid (250 mg, 1.20 mmol), 3-aminobenzenesulfonamide (207.3 mg, 1.20 mmol) and HATU (457.8 mg, 1.20 mmol) were combined in DMF (2.5 mL) and treated with 4-methylmorpholine (397.1 μL, 3.61 mmol). The reaction was heated at 60° C. for 12 hours. The reaction was cooled to 25° C. The precipitate was filtered to yield N-(3-sulfamoylphenyl)-2-(triazolo[4,5-b]pyridin-3-yloxy)quinoline-3-carboxamide as a solid. ESI-MS m/z calc. 461.09, found 461.3 (M+1)+; Retention time: 1.35 minutes (3 minutes run).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09139529B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-73b9db87ee444376a9b291603b52f0a8 |
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| Source note | uspto-grants-2015_09 |
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