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Pyridine → N-(4-chloro-3-nitrophenyl)methanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 4-Chloro-3-nitroaniline | HCID 12477 | — |
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-(4-chloro-3-nitrophenyl)methanesulfonamide | HCID 3755760 | 92.2% |
反応手順
A mixture of 4-chloro-3-nitroaniline (5.0 g, 29 mmol), methanesulfonyl chloride (2.37 mL, 30.4 mmol) and pyridine (5.9 mL, 72.4 mmol) in THF (100 mL) was stirred for 24 h. Poured in 1M HCl (500 mL). The resulting precipitate was filtered and air-dried to provide the title compound as a solid (6.7 g, 92%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09139536B2 |
| 出典データセット | uspto-grants-2015_09 |
| ORD ID | ord-ff7cc3558c8a4c9a916f098f2c19f50a |
| 出典メモ | uspto-grants-2015_09 |