Trifluoroacetic acid → (S)-Methyl 2-(6-((4'-(azetidin-3-yloxy)-2',6'-dimethylbiphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetate 2,2,2-trifluoroacetate

Participants

Reaction Steps

(S)-tert-Butyl 3-((3′-(((3-(2-methoxy-2-oxoethyl)-2,3-dihydrobenzofuran-6-yl)oxy)methyl)-2,6-dimethylbiphenyl-4-yl)oxy)azetidine-1-carboxylate 14b (100 mg, 0.17 mmol) was dissolved in 5 mL of dichloromethane, followed by addition of 1 mL of trifluoroacetic acid. The reaction solution was stirred for 2 hours. The resulting solution was concentrated under reduced pressure to obtain the crude title compound

Provenance & Evidence