反应详情

Into a 500 mL round bottomed flask equipped with magnetic stirring was added tert-butyl 4-(2-nitrophenyl)piperazinecarboxylate (5.0 g, 16 mmol) in 95% EtOH (250 mL), and 10% Pd/C (2.0 g, 1.9 mmol) (Aldrich). The flask was equipped with a balloon filled with H2, and the reaction was stirred for 18 h. After filtering through a pad of Celite®, the crude material was concentrated in vacuo to afford the desired compound (4.4 g). MS (ESI, pos. ion) m/z: 278 (M+H), (ESI, neg. ion) m/z: 276 (M−H). Calc'd for C15H23N3O2: 277.18.

1. customInto a 500 mL round bottomed flask equipped
2. customThe flask was equipped with a balloon
3. additionfilled with H2
4. stirringthe reaction was stirred for 18 h
5. filtrationAfter filtering through a pad of Celite®
6. concentrationthe crude material was concentrated in vacuo