Dimethylformamide → HCID 86665810, compound

Participants

Reaction Steps

To a 500 mL beaker was added the product from Step 3 (30 g) and anhydrous dimethylformamide (50 mL). Sodium acetylide xylene slurry (22 wt %, 90 g) was dropped to the mixture through addition funnel slowly. The reaction mixture was stirred with a glass stirring bar for 10 minutes. The mixture was poured into water (400 mL). The resulting mixture was extracted with ethyl acetate (200 mL). The recovered top layer was filtered through a silica gel plug using ethyl acetate and methanol mixture as eluent. Solid product was obtained by recrystallization from condensed major fraction. The solid was filtered off and dried in vacuum oven at 60° C. for 3 hours to afford 17 g of 1-phenyl-1-(4-piperazinophenyl)-2-propyn-1-ol.

Provenance & Evidence