Dimethyl Sulfoxide → HCID 67608172, compound

Participants

Reaction Conditions

Reaction Steps

To a 1 L two-neck flask was added 4-fluorobenzophenone (100 g) and 2-methyl piperazine (60 g), triethyl amine (160 mL) and dimethyl sulfoxide (200 mL). The flask was seated in oil bath. The oil bath was heated to 100° C. for 24 hours. The mixture was cooled to room temperature and then poured into water (300 mL). The mixture was extracted with chloroform (300 mL). The bottom layer was separated and washed with water (500 mL) and brine (300 mL). The final solution was condensed and the residue was filtered off a silica gel plug. The major fraction was condensed to afford yellow oily 4-(3-methylpiperazino)benzophenone (130 g).

Provenance & Evidence