Ethyl 2-(4,6-dimethyl-5-nitropyrimidine-2-yloxy)acetate → Ethyl 2-(5-amino-4,6-dimethylpyrimidine-2-yloxy)acetate

HRID 2280889Notes

Reaction equation

[CH3:1][C:2]1[C:7]([N+:8]([O-])=O)=[C:6]([CH3:11])[N:5]=[C:4]([O:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:3]=1.[H][H]>C(O)C.[Pd]>[NH2:8][C:7]1[C:2]([CH3:1])=[N:3][C:4]([O:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[N:5][C:6]=1[CH3:11]

Participants

Conditions

Temperature: 25 °C

Procedure

Compound 6 (75.98 g) and 5% Pd—C (7.598 g, N. E. CHEMCAT, STD Type) were suspended in ethanol (760 mL). Evacuation and replacement with hydrogen were repeated three times. Subsequently, the suspension was vigorously stirred at room temperature (20 to 30° C.) for 4.5 hours under hydrogen atmosphere. After the reaction was completed, the mixture was subjected to high precision pressure filtration (0.2 μm, PTFE) and the filtered product was washed with ethanol (474 mL). The filtrate was evaporated under reduced pressure to give 66.99 g (99.9% yield) of the desired product as a pale yellow solid.

Workup

filtrationthe mixture was subjected to high precision pressure filtration (0.2 μm, PTFE)
washthe filtered product was washed with ethanol (474 mL)
customThe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record: ord-360173c0d7e94654a80bd4f0de06a275
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09139559B2

Reaction notes

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