HCID 58817553, compound → HCID 59336119, compound

HRID 2280932Notes

Reaction equation

HRID 2280932 reaction equation
C(OC([NH:8][C:9]1[C:10]([CH3:21])=[N:11][C:12]([O:16][CH2:17][C:18]([OH:20])=O)=[N:13][C:14]=1[CH3:15])=O)(C)(C)C.[CH3:22][NH:23][CH:24]1[CH2:29][CH2:28][N:27]([CH2:30][C:31]2[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][CH:32]=2)[CH2:26][CH2:25]1>>[NH2:8][C:9]1[C:14]([CH3:15])=[N:13][C:12]([O:16][CH2:17][C:18]([N:23]([CH3:22])[CH:24]2[CH2:29][CH2:28][N:27]([CH2:30][C:31]3[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:38])[F:39])=[CH:33][CH:32]=3)[CH2:26][CH2:25]2)=[O:20])=[N:11][C:10]=1[CH3:21]

Participants

3

Reactant 2

HCID 58817553HCID 58817553, compoundHCID 593361682-(5-(Tert-butoxycarbonylamino)-4,6-dimethylpyrimidine-2-yloxy)acetic acid

Product 1

HCID 59336119HCID 59336119, compound

Procedure

The title compound was synthesized from Compound 9 and N-methyl-1-(4-(trifluoromethyl)benzyl)-piperidine-4-amine in the same manner as in Example 64 and recrystallized from methylene chloride.

Workup

  1. customrecrystallized from methylene chloride

Sources & evidence

ORD record
ord-aa13fbd082e6471b94f8d0bb2c41e247
Source dataset
uspto-grants-2015_09
Patent number
US09139559B2

Reaction notes

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