1-(cyclopropylmethyl)-N-methylpiperidine-4-amine → 2-(5-amino-4,6-diisopropylpyrimidine-2-yloxy)-N-(1-(cyclopropylmethyl)piperidine-4-yl)-N-methylacetamide

Participants

Role	Name	HCID	Charge
Reactant	1-(cyclopropylmethyl)-N-methylpiperidine-4-amine	HCID 43314908	—
Reactant	Ethyl 2-(5-amino-4,6-diisopropylpyrimidine-2-yloxy)acetate	HCID 59336100	—
Product	2-(5-amino-4,6-diisopropylpyrimidine-2-yloxy)-N-(1-(cyclopropylmethyl)piperidine-4-yl)-N-methylacetamide	HCID 59336132	—

Reaction Steps

As in Example 11, a carboxylic acid derivative was synthesized from Compound 13. Then, the title compound was synthesized from the obtained carboxylic acid derivative and 1-(cyclopropylmethyl)-N-methylpiperidine-4-amine in the same manner as in Example 49.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09139559B2
Source dataset	uspto-grants-2015_09
ORD ID	ord-8e9161ce00564daa98984cf0ea6077aa
Source note	uspto-grants-2015_09