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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2280951Generated: October 26, 2026

1-Cyclopropanecarbonyl-N-methylpiperidin-4-amine → 2-(6-chloropyridazine-3-yloxy)-N-(1-(cyclopropanecarbonyl)piperidine-4-yl)-N-methylacetamide

https://huagongshe.com/reaction/2280951

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Cyclopropanecarbonyl-N-methylpiperidin-4-amineHCID 60817866—
ReactantEthyl 2-(6-chloropyridazine-3-yloxy)acetateHCID 86641965—
Product2-(6-chloropyridazine-3-yloxy)-N-(1-(cyclopropanecarbonyl)piperidine-4-yl)-N-methylacetamideHCID 8664196463%

Reaction Steps

The title compound was synthesized from ethyl 2-(6-chloropyridazine-3-yloxy)acetate and cyclopropyl(4-(methylamino)piperidine-1-yl)methanone in the same manner as in Example 105 (63% yield, in 2 steps).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09139559B2
Source datasetuspto-grants-2015_09
ORD IDord-2b16a5c472bc4296abb96b78cd687345
Source noteuspto-grants-2015_09