2-(3-phenyl-1H-pyrazol-1-yl)pyridine-3-carboxylic acid → N-{1-[Amino(oxo)acetyl]pentyl}-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide

HRID 2280960Notes

Reaction equation

HRID 2280960 reaction equation
[C:1]1([C:7]2[CH:11]=[CH:10][N:9]([C:12]3[C:17]([C:18]([OH:20])=O)=[CH:16][CH:15]=[CH:14][N:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:22][CH:23]([CH2:29][CH2:30][CH2:31][CH3:32])[CH:24]([OH:28])[C:25]([NH2:27])=[O:26]>>[NH2:27][C:25](=[O:26])[C:24]([CH:23]([NH:22][C:18](=[O:20])[C:17]1[CH:16]=[CH:15][CH:14]=[N:13][C:12]=1[N:9]1[CH:10]=[CH:11][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[N:8]1)[CH2:29][CH2:30][CH2:31][CH3:32])=[O:28]

Participants

3

Reactant 2

HCID 667199602-(3-phenyl-1H-pyrazol-1-yl)pyridine-3-carboxylic acidHCID 73425063HCID 73425063, compound

Product 1

HCID 25157358N-{1-[Amino(oxo)acetyl]pentyl}-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide

Procedure

Preparation in analogy to Example 5 by coupling 2-(3-phenyl-1H-pyrazol-1-yl)pyridine-3-carboxylic acid and 3-amino-2-hydroxyheptanamide hydrochloride and subsequent oxidation afforded 40 mg of the title compound as a white solid.

Workup

  1. customPreparation in analogy to Example 5

Sources & evidence

ORD record
ord-3706e798f83342aaa2350eb555b8f9bb
Source dataset
uspto-grants-2015_09
Patent number
US09139557B2

Reaction notes

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