5-Bromovaleric acid → 5-azidopentanoic Acid

HRID 2280973Notes

Reaction equation

Br[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7].[N-:9]=[N+:10]=[N-:11].[Na+]>>[N:9]([CH2:2][CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7])=[N+:10]=[N-:11]

Participants

Reactant 2

HCID 163685-Bromovaleric acid

HCID 33557Sodium Azide

Product 1

HCID 111161715-azidopentanoic Acid

Procedure

Reaction of 5-bromopentanoic acid and NaN3, as described for the synthesis of 6, gave 5-azidobutanoic acid 8. Saponification was not necessary. Used without further purification.

Workup

customas described for the synthesis of 6

Sources & evidence

ORD record: ord-b8098e96ab1c445189b83d6ce01f9eda
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09139565B2

Reaction notes

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