6-Bromohexanoic acid → 6-azidohexanoic Acid

HRID 2280974Notes

Reaction equation

Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8].[N-:10]=[N+:11]=[N-:12].[Na+]>>[N:10]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8])=[N+:11]=[N-:12]

Participants

Reactant 2

HCID 202106-Bromohexanoic acid

HCID 33557Sodium Azide

Product 1

HCID 110409496-azidohexanoic Acid

Procedure

Reaction of 6-bromohexanoic acid and NaN3, as described for the synthesis of 6, gave 6-Azidohexanoic acid 9. Saponification was not necessary. Used without further purification.

Workup

customas described for the synthesis of 6

Sources & evidence

ORD record: ord-acf5c510a52146be9e53360fbb403bd3
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09139565B2

Reaction notes

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