HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → HCID 71512861, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 4-Amino-2-fluoro-5-methoxybenzoic acid | HCID 52982963 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 71512861 | HCID 71512861 | 68% |
Reaction Steps
A mixture of 4-amino-2-fluoro-5-methoxybenzoic acid (600 mg, 3.24 mmol), morpholine (564 mg, 6.48 mmol), HATU ((O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate, 1.85 g, 4.86 mmol), DIPEA (diisopropyl ethylamine, 836 mg, 6.48 mmol), and CH2Cl2 (20 mL) was stirred at room temperature for 6 h. The solvent was removed under reduced pressure and the residue was purified by silica-gel column chromatography to afford the title compound (560 mg, 68%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09139566B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-fe50ad8f8dde4440bb2e7ddacff7fff9 |
| Source note | uspto-grants-2015_09 |