Boron tribromide → HCID 86687792, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (4-amino-2-fluoro-5-methoxyphenyl)(morpholino)methanone (260 mg, 1.02 mmol), BBr3 (1.28 g, 5.10 mmol), and CH2Cl2 (15 mL) was stirred at 0° C. for 2 h. The reaction was quenched by water at 0° C. The resulting mixture was extracted with EtOAc. The combined organic layer was washed with brine (20 mL), dried over sodium sulfate, and concentrated under reduced pressure. Silica-gel column chromatography afforded the title product as yellow solid (200 mg, 81%).

Provenance & Evidence